Vitamin A

Retinoids (the various forms of vitamin A) are considered the gold standard in cosmeceuticals and are used to treat over 125 skin disorders. Vitamin A is central in controlling and balancing the skin as it activates through its direct effect on DNA in the cell nucleus.
Vitamin A and its derivatives have gone through a significant evolution over the decades. Current technology has given rise to a liposomal form of retinol, a form of vitamin A that is stable, effective, and non-irritating on the skin. More recently, the highly effective form of topical retinoid therapy, HPR (Hydroxypinacolone retinoate), has been developed, which works by directly accessing retinoid receptors on the nucleus.

What is stabilised retinol with a gentle release liposome technology?
The Synergie Skin stabillised retinol with a gentle release liposome technology utilises a phospholipid liposome to encapsulate and protect the active retinol from degradation and reduce potential skin inflammation. This biocompatible lipid capsule (oil envelope) is ideal for those who are sensitive to retinol or are first-time retinol users, as the liposomal delivery system releases the active ingredient in the deeper skin layers and bypasses direct retinol contact with the skin surface to minimise potential irritation. The liposomes spread uniformly
across the skin and penetrate rapidly to target sites in the skin.

What is encapsulated retinol with ‘Release on Demand’ technology?
Another method of delivering stabilised retinol into the skin is by utilising a ‘Release on Demand’ cellulose-based polymer to safely
encapsulate and protect the active retinol. The retinol molecules remain protected in their capsule for maximum shelf life and stability and the active retinol easily releases from the protective cellulose capsule upon the gentle massaging of skin application.
The outer microcapsules break down and disintegrate during this rubbing process on the skin surface to release the active retinol
payload for controlled, targeted and continuous delivery to the target cells.  In conjunction with the encapsulated retinol with ‘Release
on Demand’ technology, Terri has also incorporated a gentle peptide resurfacing complex to amplify the skin renewal effects of the stabilised retinol. Many other retinoid products include AHAs such as lactic and glycolic acids to increase the exfoliation process with the retinol increasing the rate of cell turnover and the exfoliating acids accelerating the skin shedding process. When retinol is used in combination with alpha hydroxy acids (AHA) they can negatively interact with the retinol molecule rendering it less effective. Rather than using reactive and potentially irritating acids, Synergie Skin has added a gentle peptide resurfacing complex derived from yeast and
soy. This complex gently breaks the protein bonds between the skin’s surface cells to accelerate the skin shedding process.
The combination of the encapsulated retinol and the peptide resurfacing complex will amplify regeneration and luminosity through more effective skin surface renewal.

What is hydroxypinacolone retinoate (HPR)?
This next generation vitamin A ingredient requires no metabolic conversion by the target cell to exert its numerous beneficial effects. HPR is an ester of all-trans retinoic acid capable of binding directly to retinoid receptors and enhancing gene expression. It is the fastest acting and most potent form of vitamin A, next only to prescription retinoic acid. Clinical studies demonstrate that HPR visibly reduces the appearance of lines and wrinkles in as little as 14 days whilst also brightening, clearing, firming and plumping the skin, reducing visible pores, and normalising cell turnover and excess oil production.

The RetiGen ComplexTM
Synergie Skin has created and trademarked the RetiGen Complex™, a powerful blend of skin perfecting ingredients, including the cutting-edge hero retinoid, hydroxypinacolone retinoate. The HPR is combined with coenzyme Q10 and green tea to offer optimal antioxidant protection against free radicals, cellular ageing, environmental damage and oxidative stress.
This complex increases the skin’s ability to produce collagen and elastin while reversing and preventing the visible signs of ageing. The RetiGen ComplexTM inhibits elastase and MMPs, responsible for the breakdown of collagen and elastin. It inhibits the production of tyrosinase, one of the key enzymes involved in pigment production, thereby resulting in a brighter and more even toned complexion.